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Tissue plasminogen activator wikipedia. Ischemic stroke. There were twelve big scale, highquality trials of rtpa in acute ischemic stroke. A metaanalysis of these trials concluded that rtpa given. Stroke cleveland health facility middle for persevering with education. Definition and etiology. A stroke is defined as an acute lack of neurological function due to an atypical perfusion of brain tissue. Maximum strokes are ischemic (87%.
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